The PM wrote in the Mail on Sunday that more complicated messages were needed during the next phase of the response and as restrictions changed.
His comments come amid mounting criticism of the way restrictions have been lifted in England.
Greater Manchester mayor Andy Burnham warned the PM risked a “fracturing of national unity” if he ignores regions.
And Labour leader Sir Keir Starmer has blamed Mr Johnson for the way Wales and England have diverged on the easing of lockdown.
In his article, Mr Johnson said that the government was attempting something that has “never had to be done before”.
He also cautioned that, while the UK is “leading the global effort” to find a vaccine, it “might not come to fruition”.
Mr Johnson said he trusted the “good sense of the British people” to observe the new rules and thanked the public for “sticking with us” so far.