Tag: Animal testing

Mercola: Fast-Tracked COVID-19 Vaccine — What Could Go Wrong?

STORY AT-A-GLANCE

  • The COVID-19 vaccine may in fact be the most fast-tracked vaccine ever created in all history, which necessitates the elimination of required safety testing steps, such as animal testing
  • Pfizer in collaboration with BioNTech began human trials in the U.S. of a COVID-19 vaccine on May 11, 2020. If successful, the vaccine could be released as early as September 2020 with an FDA-approved Emergency Use Authorization (EUA)
  • Like Moderna and several other competitors, the Pfizer/BioNTech vaccine is using messenger RNA (mRNA) rather than live or attenuated (inactivated) viruses grown in animal cells
  • Previous attempts to create coronavirus vaccines have failed due to coronaviruses triggering production of two different types of antibodies — one that fights disease and one that triggers “paradoxical immune enhancement” that often results in very serious disease and/or death
  • Vaccines that caused paradoxical immune enhancement initially looked very promising as they produced very robust antibody responses. Yet when exposed to the wild virus, ferrets and children became severely ill and many died

National Institutes of Health: High exposure to radio frequency radiation associated with cancer in male rats

NTP releases final reports on rat and mouse studies of radio frequency radiation like that used in 2G and 3G cell phone technologies.

The National Toxicology Program (NTP) concluded there is clear evidence that male rats exposed to high levels of radio frequency radiation (RFR) like that used in 2G and 3G cell phones developed cancerous heart tumors, according to final reports released today. There was also some evidence of tumors in the brain and adrenal gland of exposed male rats. For female rats, and male and female mice, the evidence was equivocal as to whether cancers observed were associated with exposure to RFR. The final reports represent the consensus of NTP and a panel of external scientific experts who reviewed the studies in March after draft reports were issued in February.

National Library of Medicine: Mouse models for radiation-induced cancers

Abstract

Potential ionising radiation exposure scenarios are varied, but all bring risks beyond the simple issues of short-term survival. Whether accidentally exposed to a single, whole-body dose in an act of terrorism or purposefully exposed to fractionated doses as part of a therapeutic regimen, radiation exposure carries the consequence of elevated cancer risk. The long-term impact of both intentional and unintentional exposure could potentially be mitigated by treatments specifically developed to limit the mutations and precancerous replication that ensue in the wake of irradiation The development of such agents would undoubtedly require a substantial degree of in vitro testing, but in order to accurately recapitulate the complex process of radiation-induced carcinogenesis, well-understood animal models are necessary. Inbred strains of the laboratory mouse, Mus musculus, present the most logical choice due to the high number of molecular and physiological similarities they share with humans. Their small size, high rate of breeding and fully sequenced genome further increase its value for use in cancer research. This chapter will review relevant m. musculus inbred and F1 hybrid animals of radiation-induced myeloid leukemia, thymic lymphoma, breast and lung cancers. Method of cancer induction and associated molecular pathologies will also be described for each model.