Tag: Virologist

Bloomberg: AstraZeneca Gets $1 Billion From U.S. to Make Oxford Vaccine

AstraZeneca Plc received more than $1 billion in U.S. government funding to develop a Covid-19 vaccine from the University of Oxford, and said it has supply agreements for 400 million doses.

The investment accelerates a race to secure vaccine supplies, seen as a key step toward getting global economies moving again after a lockdown-induced slump. Stock markets have been rising and falling on developments in research labs, as investors weigh the prospects for a successful shot.

The U.K. drugmaker received the money from the U.S. Biomedical Advanced Research and Development Authority and said it has secured capacity to make 1 billion doses. The move comes as the company’s vaccine candidate is still in human trials, with no guarantee of success.

Dr. Fauci Backed Controversial Wuhan Lab with U.S. Dollars for Risky Coronavirus Research

Dr. Anthony Fauci is an adviser to President Donald Trump and something of an American folk hero for his steady, calm leadership during the pandemic crisis. At least one poll shows that Americans trust Fauci more than Trump on the coronavirus pandemic—and few scientists are portrayed on TV by Brad Pitt.

But just last year, the National Institute for Allergy and Infectious Diseases, the organization led by Dr. Fauci, funded scientists at the Wuhan Institute of Virology and other institutions for work on gain-of-function research on bat coronaviruses.


RT America: Video: The CDC is actually a vaccine company’ – Robert F. Kennedy Jr

Attorney Robert F. Kennedy Jr. of Children’s Health Defense joins to discuss the much-touted HPV vaccine, which new evidence shows may be ineffective and why it has done tremendous harm. He also explains how legal loopholes exempt vaccine makers from rigorous testing. He goes on to discuss the revolving door between Big Pharma and the bodies that are supposed to oversee it and curtail its abuses. He argues that regulatory capture has turned the Centers for Disease Control and Prevention (CDC) into “a vaccine company.”

The National Library of Medicine: Occurrence of Kawasaki disease after simultaneous immunization

A recent population‐based study has shown that vaccinations did not increase the risk of Kawasaki disease (KD).1 In contrast, various vaccines, including those against rotavirus, hepatitis B, and influenza, have been suggested to be triggers for KD occurrence.2 We report a pediatric case of KD that occurred after simultaneous immunization with measles/rubella, varicella, and pneumococcal vaccine, suggesting that the vaccination is associated with KD.

A healthy 14‐month‐old Japanese girl without any past or family histories had a fever the day after concomitant inoculation (day 1 of illness) with initial measles/rubella (MR), initial varicella, and fourth pneumococcal vaccination. On day 2 of illness, rash/redness appeared around the previous bacille Calmette–Guérin (BCG) inoculation site (Fig. 1a). On day 4 of illness, she had conjunctival congestion, rash on the trunk, oral‐mucosal inflammation, and reddening of palms with C‐reactive protein (CRP) 4.2 mg/dL and white blood cell count 18 200/μL. On day 5 of illness with persistent fever, she was diagnosed with definite KD on meeting five of the six KD criteria. Given that KD symptoms were resolving with decreasing serum CRP (3.2 mg/dL), aspirin was given on its own without i.v. immunoglobulin. Rash/redness around the BCG inoculation site was still evident, which became a crust on day 11 of illness (Fig. 1b). Echocardiography indicated neither coronary artery sequelae nor heart lesions throughout the clinical course. Antibody analysis on day 6 of illness was as follows: rubella (−), Varicella‐Zoster virus (VZV) (−), Epstein–Barr virus (−), and measles immunoglobulin (Ig)G (−)/IgM (+). Rubella, VZV, and measles seroconverted on antibody analysis 3 months after immunization. The parents of the patient provided informed consent for the publication of this report.

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Bacille Calmette–Guérin (BCG) inoculation site on (a) day 2 and (b) day 11. (a) Redness at the site of previous BCG inoculation is evident. (b) Formation of crust at the BCG inoculation site, which is pathognomonic for Kawasaki disease.

Kawasaki disease symptoms in this patient appeared after simultaneous inoculation with MR, varicella, and pneumococcal vaccine. We diagnosed KD based on clinical symptoms and considered that vaccinations might be associated with KD occurrence. We suggest two possibilities to explain this clinical manifestation: triggered by one of the vaccinations, possibly measles, or by a reaction to the simultaneous immunization itself.

First, KD may have been triggered by one of the vaccinations, possibly measles. Vaccination sometimes accompanies/causes “fever” or “infection‐like symptoms”; therefore, we must distinguish KD from short‐term accompanying events with vaccination. This patient had rash/redness around the BCG inoculation site. It appeared soon after vaccination and gradually became a crust, and these findings are pathognomonic for KD. Rash/redness followed by crust formation at the BCG inoculation site has been observed in 70% of KD patients aged 3–20 months.3 The presence of five of the six KD criteria and this change at the BCG inoculation site were strongly suggestive of KD. In addition, we need to consider that this patient developed measles after immunization. Six days after vaccination, her serum measles antibody titer was elevated: measles IgG (−)/IgM (+). This result, however, is consistent with the reaction caused by measles vaccination. Also, the occurrence of fever soon after vaccination may rule out the possibility of modified measles caused by live vaccination, because this always takes several days to cause fever.

An association between measles or measles vaccination and KD occurrence has been previously reported. In a 6‐month‐old infant, KD occurred 2 weeks after measles. This suggests that measles triggered the KD through immunoreaction against measles infection.4 An earlier report described the isolation of measles virus from a pediatric patient with KD a few weeks after measles vaccination.5 Taken together, a possible association between vaccinations (especially measles) and KD occurrence is suggested, although it is still possible, however, that the timing of vaccinations just before the onset of Kawasaki disease was coincidental.

Second, vaccinations other than measles, that is, rubella, varicella, and pneumococcal vaccine, may have been associated with KD occurrence in this case. In particular, simultaneous inoculation may also be a cause of KD. Fever just after vaccination is possibly related to concomitant inoculation. Although simultaneous inoculation was shown not to increase side‐effects, it may trigger a stronger immunoreaction, causing fever and KD in this case.

Another point may be noteworthy. The present patient had the onset of KD only 1 day after the immunization: this rapidity/temporality is very limited. According to the review by Chang and Islam, only four cases were reported in which KD manifested ≤1 day after immunization, or KD symptoms appeared ≤12 h after the second shot of various vaccines.2 They speculated that this rapidity of symptom occurrence reflects “antigen sensitization” due to previous exposure to antigens, and is an immune‐mediated phenomenon. In the present case, however, only pneumococcal vaccination was the fourth shot, with the remaining vaccines (MR and varicella) being given for the first time.

In conclusion, the present single case supports the suggestion that vaccination triggers KD. Information on cases of KD associated with vaccination should be accumulated to clarify the pathophysiology or etiology of KD.


The authors declare no conflict of interests.